Neuroprotective Effects of the Cultivated Chondrus crispus in a C. elegans Model of Parkinson’s Disease
Identifieur interne : 000629 ( Main/Exploration ); précédent : 000628; suivant : 000630Neuroprotective Effects of the Cultivated Chondrus crispus in a C. elegans Model of Parkinson’s Disease
Auteurs : Jinghua Liu ; Arjun H. Banskota ; Alan T. Critchley ; Jeff Hafting ; Balakrishnan PrithivirajSource :
- Marine Drugs [ 1660-3397 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Animals, Genetically Modified, Aquaculture, Bacterial Proteins (genetics), Bacterial Proteins (metabolism), Behavior, Animal (drug effects), Caenorhabditis elegans, Caenorhabditis elegans Proteins (agonists), Caenorhabditis elegans Proteins (antagonists & inhibitors), Caenorhabditis elegans Proteins (genetics), Caenorhabditis elegans Proteins (metabolism), Chondrus (chemistry), Chondrus (growth & development), Dietary Supplements, Disease Models, Animal, Dopaminergic Neurons (drug effects), Dopaminergic Neurons (metabolism), Dopaminergic Neurons (pathology), Humans, Luminescent Proteins (genetics), Luminescent Proteins (metabolism), Microscopy, Fluorescence, Movement (drug effects), Neuroprotective Agents (administration & dosage), Neuroprotective Agents (therapeutic use), Neurotoxins (antagonists & inhibitors), Neurotoxins (toxicity), Oxidative Stress (drug effects), Parkinson Disease (diet therapy), Parkinson Disease (metabolism), Parkinson Disease (pathology), Plant Extracts (administration & dosage), Plant Extracts (therapeutic use), Recombinant Fusion Proteins (metabolism), Seaweed (chemistry), Seaweed (growth & development), alpha-Synuclein (antagonists & inhibitors), alpha-Synuclein (genetics), alpha-Synuclein (metabolism).
- MESH :
- chemical , administration & dosage : Neuroprotective Agents, Plant Extracts.
- chemical , agonists : Caenorhabditis elegans Proteins.
- chemical , antagonists & inhibitors : Caenorhabditis elegans Proteins, Neurotoxins, alpha-Synuclein.
- chemical , genetics : Bacterial Proteins, Caenorhabditis elegans Proteins, Luminescent Proteins, alpha-Synuclein.
- chemical , metabolism : Bacterial Proteins, Caenorhabditis elegans Proteins, Luminescent Proteins, Recombinant Fusion Proteins, alpha-Synuclein.
- chemistry : Chondrus, Seaweed.
- diet therapy : Parkinson Disease.
- drug effects : Behavior, Animal, Dopaminergic Neurons, Movement, Oxidative Stress.
- growth & development : Chondrus, Seaweed.
- metabolism : Dopaminergic Neurons, Parkinson Disease.
- pathology : Dopaminergic Neurons, Parkinson Disease.
- chemical , therapeutic use : Neuroprotective Agents, Plant Extracts.
- chemical , toxicity : Neurotoxins.
- Animals, Animals, Genetically Modified, Aquaculture, Caenorhabditis elegans, Dietary Supplements, Disease Models, Animal, Humans, Microscopy, Fluorescence.
Abstract
Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the elderly people, currently with no cure. Its mechanisms are not well understood, thus studies targeting cause-directed therapy or prevention are needed. This study uses the transgenic
Url:
DOI: 10.3390/md13042250
PubMed: 25874922
PubMed Central: 4413210
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroprotective Effects of the Cultivated <italic>Chondrus crispus</italic> in a <italic>C. elegans</italic> Model of Parkinson’s Disease</title><author><name sortKey="Liu, Jinghua" sort="Liu, Jinghua" uniqKey="Liu J" first="Jinghua" last="Liu">Jinghua Liu</name><affiliation><nlm:aff id="af1-marinedrugs-13-02250">Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, P.O. Box 550, Truro, NS B2N 5E3, Canada; E-Mail:<email>j.liu@dal.ca</email></nlm:aff></affiliation></author><author><name sortKey="Banskota, Arjun H" sort="Banskota, Arjun H" uniqKey="Banskota A" first="Arjun H." last="Banskota">Arjun H. Banskota</name><affiliation><nlm:aff id="af2-marinedrugs-13-02250">Aquatic and Crop Resource Development, National Research Council Canada, 1411 Oxford Street, Halifax, NS B3H 3Z1, Canada; E-Mail:<email>Arjun.Banskota@nrc-cnrc.gc.ca</email></nlm:aff></affiliation></author><author><name sortKey="Critchley, Alan T" sort="Critchley, Alan T" uniqKey="Critchley A" first="Alan T." last="Critchley">Alan T. Critchley</name><affiliation><nlm:aff id="af3-marinedrugs-13-02250">Acadian Seaplants Limited, 30 Brown Avenue, Dartmouth, NS B3B 1X8, Canada; E-Mails:<email>Alan.Critchley@acadian.ca</email> (A.T.C.);<email>jhafting@acadian.ca</email> (J.H.)</nlm:aff></affiliation></author><author><name sortKey="Hafting, Jeff" sort="Hafting, Jeff" uniqKey="Hafting J" first="Jeff" last="Hafting">Jeff Hafting</name><affiliation><nlm:aff id="af3-marinedrugs-13-02250">Acadian Seaplants Limited, 30 Brown Avenue, Dartmouth, NS B3B 1X8, Canada; E-Mails:<email>Alan.Critchley@acadian.ca</email> (A.T.C.);<email>jhafting@acadian.ca</email> (J.H.)</nlm:aff></affiliation></author><author><name sortKey="Prithiviraj, Balakrishnan" sort="Prithiviraj, Balakrishnan" uniqKey="Prithiviraj B" first="Balakrishnan" last="Prithiviraj">Balakrishnan Prithiviraj</name><affiliation><nlm:aff id="af1-marinedrugs-13-02250">Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, P.O. 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Box 550, Truro, NS B2N 5E3, Canada; E-Mail:<email>j.liu@dal.ca</email></nlm:aff></affiliation></author><author><name sortKey="Banskota, Arjun H" sort="Banskota, Arjun H" uniqKey="Banskota A" first="Arjun H." last="Banskota">Arjun H. Banskota</name><affiliation><nlm:aff id="af2-marinedrugs-13-02250">Aquatic and Crop Resource Development, National Research Council Canada, 1411 Oxford Street, Halifax, NS B3H 3Z1, Canada; E-Mail:<email>Arjun.Banskota@nrc-cnrc.gc.ca</email></nlm:aff></affiliation></author><author><name sortKey="Critchley, Alan T" sort="Critchley, Alan T" uniqKey="Critchley A" first="Alan T." last="Critchley">Alan T. Critchley</name><affiliation><nlm:aff id="af3-marinedrugs-13-02250">Acadian Seaplants Limited, 30 Brown Avenue, Dartmouth, NS B3B 1X8, Canada; E-Mails:<email>Alan.Critchley@acadian.ca</email> (A.T.C.);<email>jhafting@acadian.ca</email> (J.H.)</nlm:aff></affiliation></author><author><name sortKey="Hafting, Jeff" sort="Hafting, Jeff" uniqKey="Hafting J" first="Jeff" last="Hafting">Jeff Hafting</name><affiliation><nlm:aff id="af3-marinedrugs-13-02250">Acadian Seaplants Limited, 30 Brown Avenue, Dartmouth, NS B3B 1X8, Canada; E-Mails:<email>Alan.Critchley@acadian.ca</email> (A.T.C.);<email>jhafting@acadian.ca</email> (J.H.)</nlm:aff></affiliation></author><author><name sortKey="Prithiviraj, Balakrishnan" sort="Prithiviraj, Balakrishnan" uniqKey="Prithiviraj B" first="Balakrishnan" last="Prithiviraj">Balakrishnan Prithiviraj</name><affiliation><nlm:aff id="af1-marinedrugs-13-02250">Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, P.O. Box 550, Truro, NS B2N 5E3, Canada; E-Mail:<email>j.liu@dal.ca</email></nlm:aff></affiliation></author></analytic><series><title level="j">Marine Drugs</title><idno type="eISSN">1660-3397</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Genetically Modified</term><term>Aquaculture</term><term>Bacterial Proteins (genetics)</term><term>Bacterial Proteins (metabolism)</term><term>Behavior, Animal (drug effects)</term><term>Caenorhabditis elegans</term><term>Caenorhabditis elegans Proteins (agonists)</term><term>Caenorhabditis elegans Proteins (antagonists & inhibitors)</term><term>Caenorhabditis elegans Proteins (genetics)</term><term>Caenorhabditis elegans Proteins (metabolism)</term><term>Chondrus (chemistry)</term><term>Chondrus (growth & development)</term><term>Dietary Supplements</term><term>Disease Models, Animal</term><term>Dopaminergic Neurons (drug effects)</term><term>Dopaminergic Neurons (metabolism)</term><term>Dopaminergic Neurons (pathology)</term><term>Humans</term><term>Luminescent Proteins (genetics)</term><term>Luminescent Proteins (metabolism)</term><term>Microscopy, Fluorescence</term><term>Movement (drug effects)</term><term>Neuroprotective Agents (administration & dosage)</term><term>Neuroprotective Agents (therapeutic use)</term><term>Neurotoxins (antagonists & inhibitors)</term><term>Neurotoxins (toxicity)</term><term>Oxidative Stress (drug effects)</term><term>Parkinson Disease (diet therapy)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Plant Extracts (administration & dosage)</term><term>Plant Extracts (therapeutic use)</term><term>Recombinant Fusion Proteins (metabolism)</term><term>Seaweed (chemistry)</term><term>Seaweed (growth & development)</term><term>alpha-Synuclein (antagonists & inhibitors)</term><term>alpha-Synuclein (genetics)</term><term>alpha-Synuclein (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Neuroprotective Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="agonists" xml:lang="en"><term>Caenorhabditis elegans Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Caenorhabditis elegans Proteins</term><term>Neurotoxins</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bacterial Proteins</term><term>Caenorhabditis elegans Proteins</term><term>Luminescent Proteins</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Bacterial Proteins</term><term>Caenorhabditis elegans Proteins</term><term>Luminescent Proteins</term><term>Recombinant Fusion Proteins</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Chondrus</term><term>Seaweed</term></keywords><keywords scheme="MESH" qualifier="diet therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Behavior, Animal</term><term>Dopaminergic Neurons</term><term>Movement</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Chondrus</term><term>Seaweed</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dopaminergic Neurons</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dopaminergic Neurons</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Neuroprotective Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Neurotoxins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Genetically Modified</term><term>Aquaculture</term><term>Caenorhabditis elegans</term><term>Dietary Supplements</term><term>Disease Models, Animal</term><term>Humans</term><term>Microscopy, Fluorescence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the elderly people, currently with no cure. Its mechanisms are not well understood, thus studies targeting cause-directed therapy or prevention are needed. This study uses the transgenic <italic>Caenorhabditis elegans</italic> PD model. We demonstrated that dietary supplementation of the worms with an extract from the cultivated red seaweed <italic>Chondrus crispus</italic> decreased the accumulation of α-synulein and protected the worms from the neuronal toxin-, 6-OHDA, induced dopaminergic neurodegeneration. These effects were associated with a corrected slowness of movement. We also showed that the enhancement of oxidative stress tolerance and an up-regulation of the stress response genes, <italic>sod-3</italic> and <italic>skn-1</italic>, may have served as the molecular mechanism for the <italic>C. crispus</italic>-extract-mediated protection against PD pathology. Altogether, apart from its potential as a functional food, the tested red seaweed, <italic>C. crispus</italic>, might find promising pharmaceutical applications for the development of potential novel anti-neurodegenerative drugs for humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bernheimer, H" uniqKey="Bernheimer H">H. Bernheimer</name></author><author><name sortKey="Birkmayer, W" uniqKey="Birkmayer W">W. Birkmayer</name></author><author><name sortKey="Hornykiewicz, O" uniqKey="Hornykiewicz O">O. Hornykiewicz</name></author><author><name sortKey="Jellinger, K" uniqKey="Jellinger K">K. Jellinger</name></author><author><name sortKey="Seitelberger, F" uniqKey="Seitelberger F">F. Seitelberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klein, C" uniqKey="Klein C">C. Klein</name></author><author><name sortKey="Westenberger, A" uniqKey="Westenberger A">A. 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Martinez-Finley</name></author><author><name sortKey="Caito, S" uniqKey="Caito S">S. Caito</name></author><author><name sortKey="Slaughter, J C" uniqKey="Slaughter J">J.C. Slaughter</name></author><author><name sortKey="Aschner, M" uniqKey="Aschner M">M. Aschner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenner, S" uniqKey="Brenner S">S. Brenner</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Banskota, Arjun H" sort="Banskota, Arjun H" uniqKey="Banskota A" first="Arjun H." last="Banskota">Arjun H. Banskota</name><name sortKey="Critchley, Alan T" sort="Critchley, Alan T" uniqKey="Critchley A" first="Alan T." last="Critchley">Alan T. Critchley</name><name sortKey="Hafting, Jeff" sort="Hafting, Jeff" uniqKey="Hafting J" first="Jeff" last="Hafting">Jeff Hafting</name><name sortKey="Liu, Jinghua" sort="Liu, Jinghua" uniqKey="Liu J" first="Jinghua" last="Liu">Jinghua Liu</name><name sortKey="Prithiviraj, Balakrishnan" sort="Prithiviraj, Balakrishnan" uniqKey="Prithiviraj B" first="Balakrishnan" last="Prithiviraj">Balakrishnan Prithiviraj</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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